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Detrusor External Sphincter Dyssynergia (DESD)
DESD is a serious urologic condition most frequently seen in patients with spinal cord injury and multiple sclerosis. It is caused by lesions between the brain stem and the lower part (sacral region) of the spinal cord. Damage to the nervous system can create a lack of coordination between the bladder and the external sphincter muscle, which is the muscle that controls the emptying of the bladder.

As a result, the bladder can't empty completely, which creates a buildup of urinary pressure. DESD is a combination of these two factors and can lead to serious urinary tract damage and life-threatening consequences.